Abstract
New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 29 new chemical entities (NCEs) that were approved for the first time in 2015.
MeSH terms
-
Anti-Infective Agents / chemical synthesis
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
-
Antineoplastic Agents / chemical synthesis
-
Cardiovascular Agents / chemical synthesis
-
Central Nervous System Agents / chemical synthesis
-
Chemistry Techniques, Synthetic
-
Drug Discovery / methods*
-
Gastrointestinal Agents / chemical synthesis
-
Hypoglycemic Agents / chemical synthesis
-
Pharmaceutical Preparations / chemical synthesis*
-
Receptors, Thrombopoietin / agonists
Substances
-
Anti-Infective Agents
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antineoplastic Agents
-
Cardiovascular Agents
-
Central Nervous System Agents
-
Gastrointestinal Agents
-
Hypoglycemic Agents
-
Pharmaceutical Preparations
-
Receptors, Thrombopoietin